Cannabinoids: Is any of a group of closely related compounds that include cannabinol and the active constituents of cannabis. The best studied cannabinoids include tetrahydrocannabinol (THC), cannabidiol (CBD) and cannabinol (CBN).
A cannabinoid is a chemical compound that acts on cannabinoid receptors in cells that alter neurotransmitter release in the brain. Ligands for these receptor proteins include the endocannabinoids, the phytocannabinoids, and synthetic cannabinoids.
Cannabinoid receptors: Before the 1980s, it was often speculated that cannabinoids produced their physiological and behavioral effects via nonspecific interaction with cell membranes, instead of interacting with specific membrane-bound receptors. The discovery of the first cannabinoid receptors in the 1980s helped to resolve this debate. These receptors are common in animals, and have been found in mammals, birds, fish, and reptiles. At present, there are two known types of cannabinoid receptors, termed CB1 and CB2, with mounting evidence of more. The human brain has more cannabinoid receptors than any otherG protein-coupled receptor (GPCR) type.
Cannabidiol or (CBD): is a compound that is one of the main constituents of cannabis. CBD-Dominant which industrial hemp is means strains or products that are CBD-rich, but have very little THC content. Recent evidence shows that the compound counteracts cognitive impairment associated with the use of cannabis.Cannabidiol has little affinity for CB1 and CB2 receptors but acts as an indirect antagonist of cannabinoid agonists. It was found to be an antagonist at the putative new cannabinoid receptor, GPR55, a GPCR expressed in the caudate nucleus and putamen. Cannabidiol has also been shown to act as a 5-HT1Areceptor agonist. CBD can interfere with the uptake of adenosine, which plays an important role in biochemical processes, such as energy transfer. It may play a role in promoting sleep.
There is tentative evidence that CBD had an anti-psychotic effect, but research in this area is has just gotten underway in 2018 and multiple clinical trials are underway and will be published mid 2019 early 2020.
CBD isolate: is a fine white powder containing 99% pure CBD. ... This may cause you to think that CBD isolate is synthetic or crafted in a lab. No! CBD isolateis an all-natural cannabinoid supplement made from hemp oil that's been refined down to pure CBD.
Distillate: is a cannabis concentrate. ... Distillation is a technique for creating cannabis extracts that are pure on a molecular level. It is possible to isolate specific cannabinoids. It is also possible to create odourless and tasteless THC (or CBD) that is 99% pure concentrate.
Orphan Drug: The FDA Orphan Drug Designation program provides orphan status to drugs and biologics which are defined as those intended for the safe and effective treatment, diagnosis or prevention of rare diseases/disorders that affect fewer than 200,000 people in the U.S., or that affect more than 200,000 persons but are not expected to recover the costs of developing and marketing a treatment drug.